{"created":"2023-06-19T10:21:48.737365+00:00","id":780,"links":{},"metadata":{"_buckets":{"deposit":"5fcfe0cd-3e93-4cc2-9877-e7777a8a2dfd"},"_deposit":{"created_by":12,"id":"780","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"780"},"status":"published"},"_oai":{"id":"oai:saitama-med.repo.nii.ac.jp:00000780","sets":["9:7:126"]},"author_link":["2628","2621","2622","2618","2627","2623","2617","2626","2615","2616","2624","2619","2620","2625"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"95","bibliographicPageStart":"91","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"埼玉医科大学雑誌"},{"bibliographic_title":"Journal of  Saitama Medical University ","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoma (TCL) of childhood rarely develops in adults. The first case of systemic EBV-positive TCL, which occurred in an adult patient with chronic myeloid leukemia who was treated with a tyrosine kinase inhibitor (TKI), is reported. The patient was treated with nilotinib (TKI) for two years. He presented with a two-month history of cervical lymphadenopathy, common cold symptoms and had high titers of EBV in peripheral blood. A lymph node biopsy showed CD8-positive atypical T cells with EBV infection. Because of the pathological finding of EBV-positive T-cell lymphoma and status of EBV reactivation, we diagnosed him with systemic EBV-positive TCL. Conventional chemotherapy followed by hematopoietic stem cell transplantation was a valuable therapeutic option for this patient. TKIs are likely to inhibit T-cell activation and proliferation, and might be involved in the onset of systemic EBV-positive TCL.\n\nSystemic Epstein-Barr virus(EBV)-positive T-cell lymphoma(TCL)は小児期に多いが,稀に成人でも発症する.今回,成人慢性白血病(CML)に対しチロシンキナーゼ阻害薬(TKI)で加療中の患者に発症したEBV-positive TCLを経験した.CMLに対しニロチニブ(TKI)で2年間加療が行われ,分子生物学的寛解の状態であった.入院2ヵ月前より頸部リンパ節腫脹,感冒様症状がみられ,末梢血の単核球中にEBVの高い増殖を認めた.リンパ節生検で,CD8陽性の異型リンパ球にEBVの感染が確認された.全身でのEBVの再活性化,EBV陽性T細胞性リンパ腫の所見から,systemic EBV-positive TCLと診断した.化学療法後の造血幹細胞移植が本症例において有効であった.TKIはT細胞の免疫応答を阻害する報告があり,本症例でsystemic EBV-positive TCLの発症に関与した可能性がある.(著者抄録)","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"埼玉医科大学医学会"}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"埼玉医科大学雑誌"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.saitama-med.ac.jp/jsms/vol47/jsms47_091-095.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN0009506X","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-5074","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_24":{"attribute_name":"記事区分","attribute_value_mlt":[{"subitem_text_value":"症例報告 / Case report"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 佑加"},{"creatorName":"タナカ, ユウカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阿南, 朋恵"},{"creatorName":"アナン, トモエ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"多林, 孝之"},{"creatorName":"タバヤシ, タカユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"得平, 道英"},{"creatorName":"トクヒラ, ミチヒデ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"百瀬, 修二"},{"creatorName":"モモセ, シュウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2619","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田丸, 淳一"},{"creatorName":"タマル, ジュンイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2620","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木崎, 昌弘"},{"creatorName":"キザキ, マサヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2621","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Yuka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2622","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Anan, Tomoe","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2623","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tabayashi, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2624","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokuhira, Michihide","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2625","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Momose, Shuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2626","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamaru, Jun-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2627","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kizaki, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2628","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-28"}],"displaytype":"detail","filename":"jsms47_2_091-095.pdf","filesize":[{"value":"805.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"埼玉医科大学雑誌47巻2号91-95頁","url":"https://saitama-med.repo.nii.ac.jp/record/780/files/jsms47_2_091-095.pdf"},"version_id":"8b7ee25c-135e-4458-98b7-0997d005ae57"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ウイルス活性化","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍-多発性原発","subitem_subject_scheme":"Other"},{"subitem_subject":"*白血病-BCR-ABL陽性慢性骨髄性(薬物療法)","subitem_subject_scheme":"Other"},{"subitem_subject":"*リンパ腫-T細胞性(病因,病理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"*Epstein-Barrウイルス感染症(化学的誘発,病理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"*Nilotinib(治療的利用,毒性・副作用)","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"中年(45〜64)","subitem_subject_scheme":"Other"},{"subitem_subject":"男","subitem_subject_scheme":"Other"},{"subitem_subject":"tyrosine kinase inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nilotinib","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epstein-Barr virus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"systemic Epstein-Barr virus-positive T-cell lymphoma of childhood","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"チロシンキナーゼ阻害薬で治療中の慢性骨髄性白血病患者に発症したSystemic Epstein-Barr virus-positive T-cell lymphoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"チロシンキナーゼ阻害薬で治療中の慢性骨髄性白血病患者に発症したSystemic Epstein-Barr virus-positive T-cell lymphoma"},{"subitem_title":"Systemic Epstein-Barr virus-positive T-cell lymphoma in an adult patient with chronic myeloid leukemia receiving a tyrosine kinase inhibitor","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"12","path":["126"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-10-28"},"publish_date":"2021-10-28","publish_status":"0","recid":"780","relation_version_is_last":true,"title":["チロシンキナーゼ阻害薬で治療中の慢性骨髄性白血病患者に発症したSystemic Epstein-Barr virus-positive T-cell lymphoma"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-06-19T10:29:38.982461+00:00"}