{"created":"2023-06-19T10:21:39.619495+00:00","id":633,"links":{},"metadata":{"_buckets":{"deposit":"6a217740-7970-4e40-9b75-b0b8bc72cbe6"},"_deposit":{"created_by":12,"id":"633","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"633"},"status":"published"},"_oai":{"id":"oai:saitama-med.repo.nii.ac.jp:00000633","sets":["6:10:90"]},"author_link":["2181","2180"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-23"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"埼玉医科大学"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"平成29年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of our study was to evaluate the use of dopamine transporter (DAT) SPECT and I-MIBG myocardial scintigraphy to determine the clinical severity of Parkinson disease (PD), with a focus on motor impairments affecting activities of daily living (ADLs).","subitem_description_type":"Abstract"},{"subitem_description":"Data for 65 consecutive PD patients who underwent both DAT and MIBG imaging were reviewed. Associations between imaging variables and Hoehn and Yahr (H&Y) staging or self-supportive care ratings were investigated. Univariate and multivariate regression analyses were performed to determine the factors associated with ADLs.","subitem_description_type":"Abstract"},{"subitem_description":"After applying the exclusion criteria, 45 patients were analyzed (age, 73.1 ± 9.3 years; 23 males; H&Y stage 1: n = 12, stage 2: n = 14, stage 3: n = 10, stage 4: n = 5, and stage 5: n = 4; self-supportive care rating-dependent ADLs: n = 29). Dopamine transporter variables were significantly associated with the clinical severity of PD as assessed by H&Y staging, whereas MIBG variables were not. Dopamine transporter variables gradually decreased throughout progressive stages, whereas the MIBG variables changed only in the advanced stages. In a multivariate analysis including clinical and imaging variables, both lower DAT and MIBG uptakes were significantly associated with dependent ADL status (P = 0.028 and 0.034, respectively).","subitem_description_type":"Abstract"},{"subitem_description":"In patients with PD, DAT SPECT and MIBG myocardial scintigraphy were associated with ADL status; DAT SPECT was a stronger indicator of severity than MIBG myocardial scintigraphy in the early and middle stages.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"32409甲第1381号"}]},"item_10006_relation_14":{"attribute_name":"掲載誌名","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Clinical nuclear medicine"}]}]},"item_10006_relation_15":{"attribute_name":"掲載誌情報","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"出版社サイト"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://insights.ovid.com/pubmed?pmid=27775946","subitem_relation_type_select":"URI"}}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡野, 奈々美"},{"creatorName":"オカノ, ナナミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okano, Nanami","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2181","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-30"}],"displaytype":"detail","filename":"1381-1.pdf","filesize":[{"value":"98.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容の要旨","url":"https://saitama-med.repo.nii.ac.jp/record/633/files/1381-1.pdf"},"version_id":"afa21cef-c024-44c2-8324-a8b960cbbeaf"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-30"}],"displaytype":"detail","filename":"1381-2.pdf","filesize":[{"value":"114.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文審査の結果の要旨","url":"https://saitama-med.repo.nii.ac.jp/record/633/files/1381-2.pdf"},"version_id":"8d0811c3-94b9-4a22-816e-32f19ce432ae"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"3-Iodobenzylguanidine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aged","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aged, 80 and over","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dopamine Plasma Membrane Transport Proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Female","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Middle Aged","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Myocardial Perfusion Imaging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Parkinson Disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Radiopharmaceuticals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tomography, Emission-Computed, Single-Photon","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"パーキンソン病の進行度におけるDAT SPECTとMIBG 心筋シンチグラフィー所見の比較","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"パーキンソン病の進行度におけるDAT SPECTとMIBG 心筋シンチグラフィー所見の比較"},{"subitem_title":"Comparison of Dopamine Transporter SPECT and 123I-MIBG Myocardial Scintigraphy to Assess Clinical Severity in Patients With Parkinson Disease.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"12","path":["90"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-30"},"publish_date":"2018-05-30","publish_status":"0","recid":"633","relation_version_is_last":true,"title":["パーキンソン病の進行度におけるDAT SPECTとMIBG 心筋シンチグラフィー所見の比較"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-06-19T10:34:10.969662+00:00"}