{"created":"2023-06-19T10:21:39.503322+00:00","id":631,"links":{},"metadata":{"_buckets":{"deposit":"4752f80e-c1d7-4837-ab52-4a71b534bf63"},"_deposit":{"created_by":12,"id":"631","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"631"},"status":"published"},"_oai":{"id":"oai:saitama-med.repo.nii.ac.jp:00000631","sets":["6:10:90"]},"author_link":["2176","2177"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-23"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"埼玉医科大学"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"平成29年度","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammation, oligodendrocyte loss, demyelination, and axonal degeneration. Cyclic phosphatidic acid (cPA) is a natural phospholipid mediator with a unique cyclic phosphate ring structure at the sn-2 and sn-3 positions of the glycerol backbone. We reported earlier that cPA elicits a neurotrophin-like action and protects hippocampal neurons from ischemia-induced delayed neuronal death. We designed, chemically synthesized, and metabolically stabilized derivatives of cPA: 2-carba-cPA (2ccPA), a synthesized compound in which one of the phosphate oxygen molecules is replaced with a methylene group at the sn-2 position. In the present study, we investigated whether 2ccPA exerts protective effects in oligodendrocytes and suppresses pathology in the two most common mouse models of multiple sclerosis.","subitem_description_type":"Abstract"},{"subitem_description":"To evaluate whether 2ccPA has potential beneficial effects on the pathology of multiple sclerosis, we investigated the effects of 2ccPA on oligodendrocyte cell death in vitro and administrated 2ccPA to mouse models of experimental autoimmune encephalomyelitis (EAE) and cuprizone-induced demyelination.","subitem_description_type":"Abstract"},{"subitem_description":"We demonstrated that 2ccPA suppressed the CoCl","subitem_description_type":"Abstract"},{"subitem_description":"-induced increase in the Bax/Bcl-2 protein expression ratio and phosphorylation levels of p38MAPK and JNK protein. 2ccPA treatment reduced cuprizone-induced demyelination, microglial activation, NLRP3 inflammasome, and motor dysfunction. Furthermore, 2ccPA treatment reduced autoreactive T cells and macrophages, spinal cord injury, and pathological scores in EAE, the autoimmune multiple sclerosis mouse model.","subitem_description_type":"Abstract"},{"subitem_description":"We demonstrated that 2ccPA protected oligodendrocytes via suppression of the mitochondrial apoptosis pathway. Also, we found beneficial effects of 2ccPA in the multiperiod of cuprizone-induced demyelination and the pathology of EAE. These data indicate that 2ccPA may be a promising compound for the development of new drugs to treat demyelinating disease and ameliorate the symptoms of multiple sclerosis.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"32409甲第1379号"}]},"item_10006_relation_14":{"attribute_name":"掲載誌名","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Journal of neuroinflammation"}]}]},"item_10006_relation_15":{"attribute_name":"掲載誌情報","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"出版社サイト"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521126/","subitem_relation_type_select":"URI"}}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山本, 梓司"},{"creatorName":"ヤマモト, シンジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2176","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Shinji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2177","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-30"}],"displaytype":"detail","filename":"1379-1.pdf","filesize":[{"value":"107.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容の要旨","url":"https://saitama-med.repo.nii.ac.jp/record/631/files/1379-1.pdf"},"version_id":"09299173-8344-4540-8a96-089986c6e8cb"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-30"}],"displaytype":"detail","filename":"1379-2.pdf","filesize":[{"value":"114.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文審査の結果の要旨","url":"https://saitama-med.repo.nii.ac.jp/record/631/files/1379-2.pdf"},"version_id":"2bd92d00-c4f1-4b6d-b3a5-3996168628df"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-Inflammatory Agents","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Line, Transformed","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cuprizone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Demyelinating Diseases","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Disease Models, Animal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Female","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gene Expression Regulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MAP Kinase Signaling System","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice, Inbred C57BL","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Monoamine Oxidase Inhibitors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Myelin Sheath","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NLR Family, Pyrin Domain-Containing 3 Protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phosphatidic Acids","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Proto-Oncogene Proteins c-bcl-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"p38 Mitogen-Activated Protein Kinases","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果"},{"subitem_title":"Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"12","path":["90"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-30"},"publish_date":"2018-05-30","publish_status":"0","recid":"631","relation_version_is_last":true,"title":["脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-06-19T10:34:15.695848+00:00"}